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Accepted

GWAS for Alzheimer Disease Using Genetic Similarity Clusters

Presentation or Session Status
Poster presentation
November 6, 2024
Authors
J. J. Farrell1 , C. Zhu1 , N. Kurniansyah1 , Alzheimer Disease Sequencing Project, W. S. Bush2 , E. R. Martin3 , M. A. Pericak-Vance3, L-S. Wang4 , J. L. Haines2 , X. Zhang1 , L. A. Farrer1

1 Boston University Med. Sch., Boston, MA, 2 Case Western Reserve Univ, Cleveland, OH, 3. Univ. of Miami Miller Sch. of Med., Miami, FL, 4. Univ. of Pennsylvania, Philadelphia, PA

ABCA7 deletion interacts with APOE4 to lower age-at-onset of Alzheimer disease in African-ancestry populations

Presentation or Session Status
Oral presentation
April 3, 2025
Authors
Bilcag Akgun1, Alexander V Gulyayev1, Kara L Hamilton-Nelson1, Larry D Adams1, Patrice G Whitehead1, Gary W Beecham2, Allison Caban-Holt3, Anthony J Griswold1,4, Michael L Cuccaro1,4, Katalina F McInerney5, Andrew F Zaman1, Pedro R Mena1, Izri M Martinez1, Susan H Blanton1,4, Adesola Ogunniyi6, Brian W Kunkle1,4, Jeffery M Vance1,4,5, Christiane Reitz7, Rufus O Akinyemi6, Jonathan L Haines8, Goldie S Byrd3, African Dementia Consortium (AfDC), Alzheimer's Disease Sequencing Project (ADSP), Farid Rajabli1,4, Margaret A Pericak-Vance1,4,5

1 John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, Florida, USA
2 Department of Biostatistics and Data Science, Wake Forest School University of Medicine, Winston-Salem, NC, USA
3 Maya Angelou Center for Health Equity, Wake Forest University School of Medicine, Winston-Salem, NC, USA
4 Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami Miller School of Medicine, Miami, FL, USA
5 Department of Neurology, University of Miami Miller School of Medicine, Miami, FL, USA
6 Institute for Advanced Medical Research and Training, College of Medicine, University of Ibadan, Ibadan, Nigeria
7 Gertrude H. Sergievsky Center, Taub Institute for Research on the Aging Brain, Departments of Neurology, Psychiatry, and Epidemiology, College of Physicians and Surgeons, Columbia University, New York, NY, USA
8 Institute for Computational Biology, Department of Population & Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH, USA

Gene-centric analysis using functional annotation identifies genetic associations with blood-based biomarkers of Alzheimer's disease in older adults from India

Presentation or Session Status
Invited/featured session
July 29, 2025
Authors
Jennifer A Smith, Hasan Abu-Amara, Zheng Li, Gerald D. Schellenberg, Priya Moorjani, Bharat Thyagarajan, Peifeng Hu, Aparajit Ballav Dey, Kumarasamy Thangaraj, Sharon L R Kardia, Wei Zhao, Yuk Yee Leung, Li-San Wang, Eileen M. Crimmins, Masroor Anwar, Sharmistha Dey, Xiang Zhou, Jinkook Lee

Multilingual profiles and their association with cognition and brain structure among older Indian adults

Presentation or Session Status
Invited/featured session
July 29, 2025
Authors
Miguel Arce Renteria, Iris Strangmann, Pranali Khobragade, Niranjan Khandelwal, Emma Nichols, Shrikanth Narayanan, Leon M. Aksman, Yingxu Liu, Sarah Petrosyan, Joyita Banerjee, Erik Meijer, Kirsten M Lynch, Jinkook Lee

Genetic variants associated with Alzheimer’s disease and telomere length

Presentation or Session Status
Poster presentation
July 28, 2025
Authors
Zainab Khurshid1,2, Tong Tong1,2, Olayinka Tosin1,2, John J. Farrell2, Congcong Zhu2, Alzheimer's Disease Sequencing Project, Eden R. Martin4, Will Bush5, Margaret A. Pericak-Vance4, Li-San Wang3, Gerard Schellenberg3, Jonathan L. Haines5, Kathryn L. Lunetta6, Xiaoling Zhang1,2,6, Lindsay A. Farrer1,2,6,7,8

1Bioinformatics Program, Boston University, Boston, MA, USA
2Department of Medicine (Biomedical Genetics), Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA
3Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA
4Hussman Institute of Human Genetics, University of Miami Miller School of Medicine, Miami, FL, USA
5Department of Population and Quantitative Health Sciences Case Western Reserve University, Cleveland, OH, USA
6Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA
7Departments of Neurology and Ophthalmology, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA
8Department of Epidemiology, Boston University School of Public Health, Boston, MA, USA

Gene-based association study of rare structural variants in Alzheimer's Disease

Presentation or Session Status
Poster presentation
July 28, 2025
Authors
Songmi Lee1,6, Adam C. English2, Rui Xia1, Gina Peloso3, Joshua C. Bis4, Honghuang Lin5, Seung Hoan Choi3, Nancy L. Heard-Costa3, Anita L. Destefano3, Fritz Sedlazeck2, Myriam Fornage1,6

1 The University of Texas Health Science Center at Houston, McGovern Medical School, Houston, TX, USA
2 Baylor College of Medicine Human Genome Sequencing Center, Houston, TX, USA
3 Boston University School of Public Health, Boston, MA, USA
4 University of Washington, Seattle, WA, USA
5 University of Massachusetts Chan Medical School, Worcester, MA, USA
6 The University of Texas Health Science Center at Houston, School of Public Health, Houston, TX, USA