Skip to main content

Artificial Intelligence/Machine Learning Consortium (AI/ML Consortium)

The AI/ML Consortium was established in 2021 to support the application of cognitive systems to the vast genetic, imaging, biomarker, and clinical data generated by ADSP and other NIA-funded initiatives. The collection of projects funded through the Consortium use artificial intelligence and machine learning approaches to achieve a number of goals, including, but not limited to, advancing gene discovery, modeling variant/gene action, building prognostic models based on biomarkers, and identifying opportunities for drug repurposing.

Component Type
Constituency

Associated Groups

The ADSP AI/ML Consortium is applying cognitive systems approaches to the analysis of AD genetic and related data. Analysis of the data generated and harmonized by the ADSP will help to identify new genes and genetic pathways that will reveal risk and protective factors for AD and guide the field toward novel therapeutic approaches to the disease. The AI/ML Working Group meets to share research updates on AI/ML Consortium projects and discuss collaborations within the AI/ML Consortium and between AI/ML investigators and other ADSP components.

The AI/ML Executive Committee comprises the AI/ML Consortium MPIs and NIA program officers. They meet to discuss administrative topics for the Consortium.

Associated Grants (Current)

Project # (Links to RePORTER) Grant Name Investigators FOA(s) Project Start Date Project End Date
Genetics of Deep-Learning-Derived Neuroimaging Endophenotypes for Alzheimer’s Disease Contact PI:
  • Degui Zhi (Yale University)
MPI(s):
  • Myriam Fornage (University of Texas Houston)
  • Shuiwang Ji (Texas A&M University)
Cognitive Computing of Alzheimer’s Disease Genes and Risk Contact PI:
  • Olivier Lichtarge (Baylor College of Medicine)
MPI(s):
Alzheimer’s MultiOme Data Repurposing: Artificial Intelligence, Network Medicine, and Therapeutics Discovery Contact PI:
  • Feixiong Cheng (Cleveland Clinic)
MPI(s):
  • Lynn Bekris (University of Washington)
  • James Leverenz (Cleveland Clinic)
AIM-AI: an Actionable, Integrated and Multiscale genetic map of Alzheimer’s disease via deep learning Contact PI:
  • Zhongming Zhao (University of Texas Health Science Center at Houston)
MPI(s):
  • Chris Gaiteri (Upstate Medical University)
  • Xiaoqian Jiang (University of Texas Health Science Center at Houston)
Ultrascale Machine Learning to Empower Discovery in Alzheimer’s Disease Biobanks Contact PI:
  • Paul Thompson (University of Southern California)
MPI(s):
  • Christos Davatzikos (University of Pennsylvania)
  • Heng Huang (University of Maryland)
  • Andrew Saykin (Indiana University)
  • Li Shen (University of Pennsylvania)
  • Gyungah Jun (Boston University)
  • Duygu Tosun-Turgut (University of California San Francisco)

Associated Grants (Past)

Project # (Links to RePORTER) Grant Name Investigators FOA(s) Project Start Date Project End Date
Artificial Intelligence Strategies for Alzheimers Disease Research Contact PI:
  • Jason Moore (Cedars-Sinai Medical Center)
MPI(s):
  • Marylyn Ritchie (Medical University of South Carolina)
  • Li Shen (University of Pennsylvania)
Learning the Regulatory Code of Alzheimer’s Disease Genomes Contact PI:
  • Towfique Raj (Mount Sinai)
MPI(s):
  • David Knowles (New York Genome Center)
Assessing Alzheimer Disease Risk and Heterogeneity Using Multimodal Machine Learning Approaches Contact PI:
  • Honghuang Lin (University of Massachusetts Medical School)
MPI(s):
Causal and integrative deep learning for Alzheimers disease genetics Contact PI:
  • Wei Pan (University of Minnesota)
MPI(s):