Phenotype Harmonization Consortium (ADSP-PHC)

The ADSP Phenotype Harmonization Consortium (ADSP-PHC) was established in 2021 to harmonize the rich endophenotype data across cohort studies to enable modern genomic analyses of AD/ADRD. The mission of the ADSP-PHC is to work in coordination with other ADSP Working Groups and initiatives to streamline access to endophenotype data, provide high-quality phenotype harmonization across domains, and provide comprehensive documentation of both data availability and harmonization procedures, with the goal of generating harmonized data that will become a “legacy” dataset perpetually curated and shared through the NIAGADS Data Sharing Service (DSS).

The aims of the ADSP-PHC are:

  1. Procure, collate and curate endophenotype data from ADSP cohort studies.
  2. Harmonize data from ADSP cohort studies leveraging advanced statistical approaches.
  3. Disseminate harmonized phenotypes and harmonization protocols to the research community.
  4. Educate the research community on available harmonized resources and best practices.
NIH Project Number
U24AG074855
Contact PI
Timothy "Tim" Hohman (Vanderbilt University Medical Center)
PI
Michael "Mike" Cuccaro (University of Miami)
Arthur "Art" Toga (University of Southern California)
Website(s)
ADSP Phenotype Harmonization Consortium website
Component Type
Constituency

Associated Groups

PHC WG

The ADSP Phenotype Harmonization Consortium (ADSP-PHC) was established to harmonize the rich endophenotype data across cohort studies to enable modern genomic analyses of ADRD. The mission of the ADSP-PHC is to work in coordination with other ADSP working groups and initiatives to streamline access to endophenotype data, provide high quality phenotype harmonization across domains, and provide comprehensive documentation of both data availability and harmonization procedures, with the goal of generating harmonized data that will become a “legacy” dataset perpetually curated and shared through NIAGADS. The PHC WG meets to discuss ADSP-PHC activities and share research updates.

Associated Grants (Current)

None

Associated Grants (Past)

Project # (Links to RePORTER) Grant Name Investigators FOA(s) Project Start Date Project End Date
U24AG074855 Alzheimer’s Disease Sequencing Project Phenotype Harmonization Consortium Contact PI:
  • Timothy Hohman (Vanderbilt University Medical Center)
MPI(s):
  • Michael Cuccaro (University of Miami)
  • Arthur Toga (University of Southern California)
PAR-20-099
R01AG059716 Genetic Drivers of Resilience to Alzheimer's Disease Contact PI:
  • Timothy Hohman (Vanderbilt University Medical Center)
MPI(s): 		PA-16-160