News Archive

NIAGADS has notified approved users and data downloaders about changes to file availability in the ADSP Umbrella Dataset (NG00067) that will take effect with the Round 6 (R6) WGS release later this year.

Beginning with R6:

• Individual-level gVCFs will no longer be routinely distributed. R6 gVCFs will not be included in regular distribution, and previously released individual-level gVCFs will be moved to archive storage.
• Selected files from older ADSP releases will also be archived. To help manage long-term storage costs, NIAGADS has reviewed and determined which older joint-called datasets should remain in active distribution.

This table (downloads .xls) summarizes which existing ADSP release files will remain in active distribution and which will be moved to archive storage. Individual-level gVCFs are not included in the table.

Archived files will not be deleted and may be made available by request.  If you expect to need files that will no longer be routinely available, we encourage you to download them before the R6 release.

Please contact the NIAGADS DSS Team with any questions.

ADSP foundational papers can now be found on the new Flagship Papers webpage under the Publications menu. Read these papers to learn about the ADSP, as well as data and data-related resources it has generated.

Wednesday, October 21, from 3:00 - 4:00pm 
Montreal Convention Center, Room 523AB

The CC will be hosting an ASHG Ancillary Session, Discover the Alzheimer's Disease Sequencing Project (ADSP): an Informational and Listening Session. This session will give ASHG attendees the opportunity to meet with representatives from the ADSP to learn about the project, ask questions, and provide feedback. Please encourage non-ADSP colleagues to attend!

The National Institute on Aging Genetics of Alzheimer’s Disease Data Storage Site (NIAGADS), operated by the University of Pennsylvania’s Perelman School of Medicine, was recently recognized as a 2026 AWS Champion. The AWS Champions Awards honor Amazon Web Services (AWS) customers who are setting new standards for innovation in the public sector and education. NIAGADS was recognized for building a cloud-native genomic data platform that allows researchers around the world to collaborate on the genetics of Alzheimer’s disease and related dementias. 

Virtual Workshop Aug 27, 2026

This NIA-sponsored workshop convened leading experts from academia and industry to explore how agentic AI and robotics are transforming biomedical research by accelerating the pace and rigor of scientific discovery.

The fourth release from the Alzheimer’s Disease Sequencing Project Phenotype Harmonization Consortium (ADSP-PHC), which includes harmonized phenotypes for ADSP participants with sequencing, is available in the ADSP Umbrella Dataset (NG00067v20). Importantly, this release includes harmonized diagnosis and plasma biomarkers for the first time. Existing users with approval for NG00067 will have access to PHC release 4 in alignment with their approved consent levels.

This dataset includes sequencing data and harmonized phenotypes from cohorts sequenced by the Alzheimer’s Disease Sequencing Project and other AD and Related Dementia’s studies. Samples are processed using a common workflow called VCPA (Variant Calling Pipeline and data management tool), a functionally equivalent CCDG/TOPMed pipeline.

We are delighted to share that "Key variants via the Alzheimer's Disease Sequencing Project whole genome sequence data", published in Alzheimer's & Dementia, on behalf of Alzheimer's Association, has ranked within the top 10% of most-viewed papers published by the journal in 2024 (among work published in Alzheimer's & Dementia between January 1, 2024 - December 31, 2024, view count taken at 12 months after publication.)

The University of Washington Genetic Analysis Center (GAC) has been awarded a $1.34 million contract to serve as the coordinating center for the National Institute on Aging's (NIA) Alzheimer’s Disease Sequencing Project (ADSP)—a large group of projects that aim to better understand the genetics of Alzheimer’s Disease and other forms of dementia.