The Alzheimer's Disease Sequencing Project (ADSP) and the ADSP Phenotype Harmonization Consortium (PHC) will be hosting an ISTAART Intermissions networking session at AAIC 2026 on Monday, July 13, from 12:15 - 2:00pm. The objective of this session is to engage researchers at any level who are interested in accessing and performing research using ADSP data. This networking session, led by Drs. DeStefano, Hohman, and Wang, will provide the opportunity for AAIC attendees currently using or interested in using ADSP data to connect, address data challenges, and build new collaborations. This session will provide opportunities to educate the research community about the available ADSP data, to answer specific questions about ADSP data and resources, and to enhance connections and collaborations among ADSP data users. The expected outcome is broader awareness of the ADSP resources, new ADSP data users, and new potential collaborations, all leading to more impactful research in the field of ADRD genomics.
The fourth release from the Alzheimer’s Disease Sequencing Project Phenotype Harmonization Consortium (ADSP-PHC), which includes harmonized phenotypes for ADSP participants with sequencing, is available in the ADSP Umbrella Dataset (NG00067v20). Importantly, this release includes harmonized diagnosis and plasma biomarkers for the first time. Existing users with approval for NG00067 will have access to PHC release 4 in alignment with their approved consent levels.
This dataset includes sequencing data and harmonized phenotypes from cohorts sequenced by the Alzheimer’s Disease Sequencing Project and other AD and Related Dementia’s studies. Samples are processed using a common workflow called VCPA (Variant Calling Pipeline and data management tool), a functionally equivalent CCDG/TOPMed pipeline.
We are delighted to share that "Key variants via the Alzheimer's Disease Sequencing Project whole genome sequence data", published in Alzheimer's & Dementia, on behalf of Alzheimer's Association, has ranked within the top 10% of most-viewed papers published by the journal in 2024 (among work published in Alzheimer's & Dementia between January 1, 2024 - December 31, 2024, view count taken at 12 months after publication.)
The University of Washington Genetic Analysis Center (GAC) has been awarded a $1.34 million contract to serve as the coordinating center for the National Institute on Aging's (NIA) Alzheimer’s Disease Sequencing Project (ADSP)—a large group of projects that aim to better understand the genetics of Alzheimer’s Disease and other forms of dementia.