Researchers from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium are funded by NIA to carry out analyses of ADSP data. The CHARGE team has diverse and complementary experience in bioinformatics, applied statistics and methodological development, admixture and ethnic diversity, rare variant association, network modeling, and preclinical validation of targets, as well as clinical expertise in AD. The team conducts an array of association analyses of AD and related endophenotypes to identify novel protective and risk variants. They leverage the ethnically diverse and admixed ADSP data set to perform ethnic-specific and trans-ethnic meta-analyses. They also work closely with the Accelerating Medicines Partnership (AMP) projects to perform bioinformatics and omics integrative analyses to identify putative therapeutic targets.
Associated Grants (Current)
Associated Grants (Past)
| Project # (Links to RePORTER) | Grant Name | Investigators | FOA(s) | Project Start Date | Project End Date |
|---|---|---|---|---|---|
| U01AG058589 | Therapeutic target discovery in ADSP data via comprehensive whole-genome analysis incorporating ethnic diversity and systems approaches | Contact PI:
|
PAR-17-214 | ||
| U01AG049505 | CHARGE: Identifying Risk & Protective SNV for AD in ADSP Case-control Sample | Contact PI:
|
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| R01AG033193 | AD Gene Discovery: Exome Chip, New Endophenotypes & Functional Studies in CHARGE | Contact PI:
|
PA-11-260 |