ADSP FUS and FUS 2.0 were funded by the NIA to identify, organize and collate Alzheimer’s disease and dementia data sets for whole-genome sequencing (WGS) and genome-wide array data generation with a focus on underrepresented populations and groups. These include Blacks, Hispanic/Latinos, and populations from Central and South America, the Iberian Peninsula, Iceland, Africa, and Asia. In addition, FUS harmonizes clinical data for consistency across and within WGS data sets. FUS data sets include both Alzheimer’s disease-specific cohorts as well as other cohorts with cognitive data that enable diagnosis of dementia. The long-term goals of FUS 2.0 are to:
- Move the field closer to enabling prediction of who will develop AD.
- Fully characterize AD subtypes by studying endophenotypes in diverse populations.
- Better understand the differences in the genetic underpinnings of AD pathogenesis among diverse populations.
- Identify specific therapeutic targets based on diverse populations.
FUS Awards
Whole Genome Sequencing in Ethnically Diverse Cohorts for the ADSP Follow-Up Study (FUS) (U01AG057659)
- MPIs: Margaret Pericak-Vance, Richard Mayeux, Badri Vardarajan
Additional Sequencing for the Alzheimer's Disease Sequencing Project (ADSP) (U01AG066767)
- MPIs: Jeffery Vance, Michael Cuccaro, Brian Kunkle
- MPIs: Margaret Pericak-Vance, Clifton Dalgard, Anthony Griswold, Brian Kunkle, Badri Vardarajan
Associated Groups
The ADSP Follow-Up Study Sequencing (FUS-Seq) working group meets to discuss activities of the FUS 2.0 Diversity Initiative: Recruitment and Retention of Diversity Cohorts, including challenges and progress in collecting samples for genotyping, sequencing, and harmonization.