The Alzheimer’s Disease Sequencing Project (ADSP) Functional Genomics Consortium (FunGen-AD) applies cutting-edge genomics technologies and high-throughput genetic screening to understand the functional impacts underlying the genetic basis of susceptibility to and resilience against Alzheimer’s disease and related dementias (AD/ADRD). The ultimate goal of the Consortium is to identify genetics-guided targets for the prevention, diagnosis, and treatment of AD/ADRD.
Funded FunGen-AD Projects
Genetic Modifiers of Cerebrospinal Fluid TREM2 in Alzheimer's Disease (RF1AG058501)
- MPIs: Carlos Cruchaga, Laura Piccio
Alzheimer Variants: Propagation of Shared Functional Changes Across Cellular Networks (U01AG072572)
- MPIs: Phil De Jager, Peter St. George-Hyslop
Genomic approach to identification of microglial networks involved in Alzheimer disease risk (U01AG058635)
- PI: Alison Goate
Mendelian Randomization for Unbias Biomarker Discovery for AD and Other Complex Traits (R01AG057777)
- PI: Oscar Harari
- MPIs: Richard Mayeux, Gary Miller, Giuseppe Tosto, Badri Vardarajan
Epidemiological Integration of Genetic Variants and Metabolomics Profiles in Washington Heights Columbia Aging Project (RF1AG066107)
- MPIs: Richard Mayeux, Gary Miller, Badri Vardarajan
Multi-Omic Functional Assessment of Novel AD Variants Using High-Throughput and Single-Cell Technologies (U01AG072573)
- MPIs: Tom Montine, Anshul Kundaje, Stephen Montgomery
Functional Genomic Dissection of Alzheimer’s Disease in Humans and Drosophila Models (U01AG072439)
- MPIs: Josh Shulman, Hugo Bellen, Juan Botas, Aleksandar Milosavljevic
Investigating the Functional Impact of AD Risk Genes on Neuro-Vascular Interactions (U01AG072464)
- MPIs: Sally Temple, Oscar Harari, Martin Kampmann, Celeste Karch, Kevin Pumiglia, Kristen Zuloaga
Identifying Protective Variants in Local Ancestry of African Americans for ApoE4 (RF1AG059018)
- PI: Jeff Vance
Functional Genomic Studies in Diverse Populations to Characterize Risk Loci for Alzheimer Disease (U01AG072579)
- MPIs: Jeff Vance, Derek Dykxhoorn, Tony Griswold, Juan Young
Circular RNAs and Their Interactions With RNA-Binding Proteins to Modulate AD-Related Neuropathology (U01AG072577)
- MPIs: Xiaoling Zhang, Benjamin Wolozin
Associated Groups
The FunGen Trainee Network aims to support trainee career development by fostering a collaborative community across computational and experimental research in functional genomics. The Network will provide a structured forum for trainees to present and discuss their research, gain exposure to diverse scientific approaches, and develop skills in scientific communication. Through regular meetings and ongoing interaction via a shared communication platform, the Network promotes peer mentoring, knowledge exchange, and professional growth, strengthening trainees’ career readiness and connections within the broader research community.
The FunGen xQTL Project provides comprehensive molecular quantitative trait loci (xQTL) analyses across multiple molecular phenotypes, along with integrative analysis for neurodegenerative disorders, particularly Alzheimer’s disease.
The FunGen-AD Consortium MPIs meet to discuss administrative topics for the Consortium.
The ADSP Functional Genomics Consortium (FunGen-AD) aims to apply cutting-edge genomics technologies and high-throughput genetic screening to understand the functional impacts underlying the genetic basis of susceptibility and resilience of Alzheimer’s disease, and to identify genetics-guided targets for the prevention, diagnosis, and treatment of Alzheimer’s disease and related dementias (AD/ADRD). The work group meets to discuss FunGen-AD projects and other administrative items.