Peruvian Population Reveals a Stronger APOE4 Risk Effect and Empowers Discovery of a Rare TREM2 Missense Variant in Alzheimer Disease

Bilcag Akgun (John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine), Mario Cornejo-Olivas (Neurogenetics Working Group, Universidad Cientifica del Sur, Neurogenetics Research Center, Instituto Nacional de Ciencias Neurológicas), Nicholas R Gomez (John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine), Maryenela Illanes-Manrique (Neurogenetics Working Group, Universidad Cientifica del Sur, Neurogenetics Research Center, Instituto Nacional de Ciencias Neurológicas, Atlantic Fellow for Equity in Brain Health at Global Brain Health Institute), Pedro R Mena (John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine), Larry D Adams (John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine), Katrina Celis (John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine), Patrice G Whitehead (John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine), Kara L Hamilton-Nelson (John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine), Julia Rios-Pinto (Universidad Peruana Los Andes), Angel Medina-Colque (Dirección Regional de Salud de Puno), Clifton L Dalgard (Department of Anatomy, Physiology, and Genetics, Uniformed Services University of the Health Sciences), Eden R Martin (John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Dr. John T Macdonald Foundation Department of Human Genetics, University of Miami Miller School of Medicine), Ivan Cornejo-Herrera (Hospital Hipólito Unanue de Tacna), Edward Ochoa-Valle (Hospital Regional de Cusco), Elison Sarapura-Castro (Neurogenetics Working Group, Universidad Cientifica del Sur, Neurogenetics Research Center, Instituto Nacional de Ciencias Neurológicas), Koni Mejía (Daniel Alcides Carrion National Hospital, EDMECON Continuing Medical Education), Victoria Marca-Ysabel (Neurogenetics Research Center, Instituto Nacional de Ciencias Neurológicas), Sheila Castro-Suarez (Atlantic Fellow for Equity in Brain Health at Global Brain Health Institute, CBI en Demencias y Enfermedades Desmielinizantes del Sistema Nervioso, Instituto Nacional de Ciencias Neurológicas), William F Hulme (John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine), Ioanna Konidari (John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine), Alzheimer’s Disease Sequencing Project (ADSP), Anthony J Griswold (John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Dr. John T Macdonald Foundation Department of Human Genetics, University of Miami Miller School of Medicine), Rosario Isasi (John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Dr. John T Macdonald Foundation Department of Human Genetics, University of Miami Miller School of Medicine), Katalina F McInerney (Department of Neurology, University of Miami Miller School of Medicine), Michael L Cuccaro (John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Dr. John T Macdonald Foundation Department of Human Genetics, University of Miami Miller School of Medicine), Jeffery M Vance (John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Dr. John T Macdonald Foundation Department of Human Genetics, University of Miami Miller School of Medicine, Department of Neurology, University of Miami Miller School of Medicine), Farid Rajabli (John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Dr. John T Macdonald Foundation Department of Human Genetics, University of Miami Miller School of Medicine), Margaret A Pericak-Vance (John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Dr. John T Macdonald Foundation Department of Human Genetics, University of Miami Miller School of Medicine, Department of Neurology, University of Miami Miller School of Medicine)