Explaining Differences In APOE Pathogenicity Using Evolutionary History

Brian Fulton-Howard 1,2
Tulsi Patel 1,2
Paras Garg 2,3
Andrew Sharp 2,3,
Alan Renton 1,2
Edoardo Marcora 1,2
Alison Goate 1,2

1. Ronald M. Loeb Center for Alzheimer’s Disease, Icahn School of Medicine at Mount Sinai
2. Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai
3. Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai