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Prioritizing The Likely Functional Variants Underlying Known Alzheimer Disease Associated Loci Using Multi Ancestries

Abstract or Session
Presentation or Session Status
Poster presentation
March 17-21, 2026
Authors
Yeunjoo E. Song1,2,*, Penelope Benchek1,2,*, Michelle Grunin1,2,*, Nicholas A. Kushch3, Farid Rajabli3, Giuseppe Tosto4,5, Brian W. Kunkle3,6, Li-San Wang7,8, Lindsay A. Farrer9,10, Richard Mayeux4,5, Margaret A. Pericak-Vance3,6, Gerard D. Schellenberg7, Gyungah R. Jun9,10, Christiane Reitz4,5, Adam C. Naj7,11, William S. Bush1,2 and Jonathan L. Haines1,2

for the Alzheimer's Disease Genetics Consortium (ADGC)

1 Department of Population and Quantitative Health Sciences, Case Western Reserve University School of Medicine, Cleveland, OH, USA
2 Cleveland Institute for Computational Biology, Case Western Reserve University School of Medicine, Cleveland, OH, USA
3 John P. Hussman Institute for Human Genomics, Miller School of Medicine, University of Miami, Miami, FL, USA
4 Gertrude H. Sergievsky Center, and
5 The Taub Institute for Research on Alzheimer’s Disease and The Aging Brain, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA
6 Dr. John T. Macdonald Foundation Department of Human Genetics, Miller School of Medicine, University of Miami, Miami, FL, USA
7 Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA
8 Institute for Biomedical Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
9 Department of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, MA, USA
10 Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA
11 Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA

* These first authors have made equal contributions.