Research Square

The Impact of Structural Variation on Alzheimer's Disease in the Alzheimer's Disease Sequencing Project.

Combining xQTL and genome-wide association studies from ethnically diverse populations improves druggable gene discovery.

Genetic Contributions to Alzheimer's Disease and Frontotemporal Dementia in Admixed Latin American Populations.

Large-scale Plasma Proteomic Profiling Unveils Novel Diagnostic Biomarkers and Pathways for Alzheimer's Disease.

Sex-specific Associations of Gene Expression with Alzheimer's Disease Neuropathology and Ante-mortem Cognitive Performance.

TrimNN: Characterizing cellular community motifs for studying multicellular topological organization in complex tissues.

Ancestral Genomic Functional Differences in Oligodendroglia: Implications for Alzheimer's Disease.

DNA Methylation Signature of a Lifestyle-based Resilience Index for Cognitive Health.

DNA methylation age from peripheral blood predicts progression to Alzheimer's disease, white matter disease burden, and cortical atrophy.

Genome wide association studies are enriched for interacting genes.

Polygenic proxies of age-related plasma protein levels reveal TIMP2 role in cognitive performance.

Exploring Cellular Heterogeneity: Single-Cell and Spatial Transcriptomics of Alzheimer Disease Brains and iPSC-Derived Microglia.

A network-based systems genetics framework identifies pathobiology and drug repurposing in Parkinson's disease.

Assessing the Limitations of Relief-Based Algorithms in Detecting Higher-Order Interactions.

Single-nucleus multiome analysis of human cerebellum in Alzheimer's disease-related dementia.

Variable and interactive effects of Sex, APOE

Single-nucleus multiomics reveals the disrupted regulatory programs in three brain regions of sporadic early-onset Alzheimer's disease.

Region-based analysis with functional annotation identifies genes associated with cognitive function in South Asians from India.

European and African-specific plasma protein-QTL and metabolite-QTL analyses identify ancestry-specific T2D effector proteins and metabolites.

Ubiquitin-Proteasome System in the Different Stages of Dominantly Inherited Alzheimer's Disease.

Proteogenomics in cerebrospinal fluid and plasma reveals new biological fingerprint of cerebral small vessel disease.

Midkine Attenuates A? Fibril Assembly and AmyloidPlaque Formation.

Novel early-onset Alzheimer-associated genes influence risk through dysregulation of glutamate, immune activation, and intracell signaling pathways.

SAFER: sub-hypergraph attention-based neural network for predicting effective responses to dose combinations.

Large-scale network analysis of the cerebrospinal fluid proteome identifies molecular signatures of frontotemporal lobar degeneration.

Global Perspectives on the Management of Primary Progressive Aphasia.

Multi-cohort cerebrospinal fluid proteomics identifies robust molecular signatures for asymptomatic and symptomatic Alzheimer's disease.

Deciphering the tissue-specific functional effect of Alzheimer risk SNPs with deep genome annotation.

Alzheimer's disease transcriptional landscape in ex-vivo human microglia.

Lysophosphatidylcholines are associated with P-tau181 levels in early stages of Alzheimer's Disease.

DeepN4: Learning N4ITK Bias Field Correction for T1-weighted Images.

miR-129-5p as a biomarker for pathology and cognitive decline in Alzheimer's disease.

An ANXA11 P93S variant dysregulates TDP-43 and causes corticobasal syndrome.

Structural Variation Detection and Association Analysis of Whole-Genome-Sequence Data from 16,905 Alzheimer's Diseases Sequencing Project Subjects.

Adherence type impacts completion rates of frequent mobile cognitive assessments among older adults with and without cognitive impairment.

The impact of blood MCP-1 levels on Alzheimer's disease with genetic variation of UNC5C and NAV3 loci.

Genetic overlap between Alzheimer's disease and immune-mediated diseases: An atlas of shared genetic determinants and biological convergence.

Multimodal nonlinear correlates of behavioural symptoms in frontotemporal dementia.

Proteogenomic analysis of human cerebrospinal fluid identifies neurologically relevant regulation and informs causal proteins for Alzheimer's disease.

Unique genetic architecture of CSF and brain metabolites pinpoints the novel targets for the traits of human wellness.

Accumulation of m6A exhibits stronger correlation with MAPT than ?-amyloid pathology in an APPNL-G-F /MAPTP301S mouse model of Alzheimer's disease.

A comprehensive SARS-CoV-2-human protein-protein interactome network identifies pathobiology and host-targeting therapies for COVID-19.

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